Antifungal Activity of Essential Oils against Fluconazole Resistant Fungi

Authors

  • Alpa Gopal Rabadia Department of Microbiology, SVKM’s Mithibai College of Arts, Chauhan Institute of Science, & Amrutben Jivanlal College of Commerce & Economics (affiliated to the University of Mumbai), Vile Parle (West), Mumbai 400056, India
  • Sheela D. Kama Department of Microbiology, SVKM’s Mithibai College of Arts, Chauhan Institute of Science, & Amrutben Jivanlal College of Commerce & Economics (affiliated to the University of Mumbai), Vile Parle (West), Mumbai 400056, India
  • Dilip V. Kamat Department of Microbiology, SVKM’s Mithibai College of Arts, Chauhan Institute of Science, & Amrutben Jivanlal College of Commerce & Economics (affiliated to the University of Mumbai), Vile Parle (West), Mumbai 400056, India

Keywords:

Essential oils, antifungal drug, drug resistance, synergistic action

Abstract

Pathogenic fungi like Candida albicans, Candida tropicalis and Trichophyton mentagrophytes are commonly encountered strains associated with a wide range of conditions including scalp infection, oral thrush, skin infection, and vaginal thrush. Unlike bacterial pathogens, fungal pathogens are difficult to control. Fluconazole is a commonly administered antifungal drug. The medical fraternity has been reporting an alarming increase in the development of resistance observed amongst fungal strains to Fluconazole. The present study involves screening of essential oils for their antifungal activity against Fluconazole resistant fungi. Essential oils of Black pepper, Cardamom, Cumin, Boswellia and Patcholi were selected for the study. The results indicated that all the oils inhibited fungal strains in varying degrees of dilutions. Essential oil of Boswellia was found to be the most effective in antifungal activity against Candida tropicalis and essential oil of Cardamom against Trichophyton mentagrophytes. To assess the effect of combination of essential oils with Fluconazole, synergistic action was also studied. The results indicated that essential oil of Boswellia and Fluconazole in combination acted as the most powerful antifungal agent against Candida tropicalis even at 1:10 dilution and 100μg/ml respectively. These results lead us to believe that active components present in essential oils should be a focus area of future in vivo research, especially in conjunction with existing antifungal drugs. The molecular mechanisms, mode of action, stability, toxicity, and efficacy of the active components isolated from essential oils need to be further studied and evaluated.

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Published

31-12-2011

How to Cite

1.
Alpa Gopal Rabadia, Sheela D. Kama, Dilip V. Kamat. Antifungal Activity of Essential Oils against Fluconazole Resistant Fungi. ijp [Internet]. 2011 Dec. 31 [cited 2024 Jun. 21];3(4):506-10. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/132

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Original Research Articles