Evaluation of in vitro antihelmintic activity of leaves of Butea monosperma

Authors

  • Borkar V. S. S.S.D.J. College of Pharmacy, Neminagar Chandwad, Dist: Nashik 423101(Maharashtra) India.
  • Gangurde H. H. S.S.D.J. College of Pharmacy, Neminagar Chandwad, Dist: Nashik 423101(Maharashtra) India.
  • Gulecha V. S. S.S.D.J. College of Pharmacy, Neminagar Chandwad, Dist: Nashik 423101(Maharashtra) India.
  • Bhoyar P.K. S.S.D.J. College of Pharmacy, Neminagar Chandwad, Dist: Nashik 423101(Maharashtra) India
  • Mundada A.S. S.S.D.J. College of Pharmacy, Neminagar Chandwad, Dist: Nashik 423101(Maharashtra) India

Keywords:

Anthelmintic Activity, Butea Monosperma, Pheretima Posthuma, Ascardia Galli, Raillietina spiralis, DMF (di-methyl formamide)

Abstract

The preliminary phytochemical screening was carried out on the crude extracts of the leaves of Butea Monosperma Lam along with ash values and extractive values on the powdered drug. The crude extracts were investigated for their anthelmintic activity against earthworms (Pheretima posthuma), roundworms (Ascardia galli.) and tapeworms (Raillietina spiralis). Three concentrations (25, 50 and 100 mg/mL) of each extract were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Alcohol and ethyl acetate extracts exhibited significant anthelmintic activity at highest concentration of 100 mg/mL. Albendazole in same concentration as those of extracts was included as standard reference and Di-methyl formamide as control. The anthelmintic activity of alcohol and ethyl acetate extracts of leaves of Butea Monosperma has therefore been demonstrated for the first time.

References

Chatterjee A, Chandra S. Anonymous. The

Treatise on Indian Medicinal Plants Vol II,

Pakrashi, editors. Publication and Information

Directorate, New Delhi, 1995: 73-74.

Kiritikar KR and Basu BD. Ind. Medicinal

Plants, Ed 2nd, Vol. IV, International book

distributor, Deharadun, India, 1996: 1096-

Asolkar LV, Kakkar KK. Glossary of Indian

Medicinal Plants with Active Principle, PartI, 148-149.

Chopra RN. Glossary of Indian Medicinal

Plants, CSIR, New Delhi, 42

Harborne JB. Phytochemical Methods, Ed 3rd,

Chapman and Hale Publishers, London, 2007:

-9

Anonymous, Pharmacopoeia of India, Vol II,

Govt. of India, Ministry of health and Family

Welfare, Controller of Publication, New

Delhi, 1996, 53-54

Pratt RT, Chess ER. Fluorescence of

powdered vegetable drugs in particular to

develop system of identification. J Am

Pharm Ass. 1949; 38:324-331

Kakoski CJ, Kakoski RJ, Sharma M.

Fluorescence of powdered vegetable drugs

under ultraviolet radiations. J Am Pharm Ass.

;47:715-717

Kokate CK, Purohit AP, Gokhale SB.

Practical Pharmacognocy, Ed 30, Nirali

Prakashan, Pune, 2004: 593-597

Ajaiyeoba EO, Onocha PA, Olarenwaju OT.

In vitro anthelmintic properties of Buchholzia

coriaceae and Gynandropsis gynandra extract.

Pharm Biol. 2001; 39: 217 -20.

Vigar Z. Atlas of Medical Parasitology. Ed

nd, P.G. Publishing House, Singapore,

: 242.

Dash GK, Suresh P, Kar DM, Ganpaty S,

Panda SB. Evaluation of Evolvulus alsinoides

Linn. for anthelmintic and antimicrobial

activities. J Nat Rem. 2002; 2: 182-185

Shivkumar YM, Kumar VL. Anthelmintic

activity of latex of Calotropis procera.

Pharma Biol. 2003; 41: 263-265

Kaushik RK, Katiyar JC, Sen AB. Studies on

the mode of action of anthelmintics with

Ascardia galli as a test parasite. Indian J Med

Res. 1974; 64: 1367-75.

Yadav AK. Anthelmintic activity of Gynura

angulosa against Trichinella spiralis

infections in mice. Pharmacology online

; 2:299-306

Sathe BS, Sreenivasa GM, Jayachandran E,

Sreenivasa RD and Naragund LVG.

Anthelmintic Activity of imidazolyl fluro

benzthiazole, Int. J. Chemical Science, 2006;

: 545 -552.

Mathew AS, Patel KN and Shah BK.

Investigation of Anthelmintic potential. Ind.

J. Natural Product, 2004; 14(1): 11-14

Bate-Smith EC. The phenolic constituent of

plants and their taxonomic significance,

dicotyledons. J Linn Soc Bot. 1962; 58: 95-

Martin RJ. Mode of action of anthelmintic

drugs. Vet J 1997; 154: 11-34.

Downloads

Published

09-02-2022

How to Cite

1.
Borkar V. S., Gangurde H. H., Gulecha V. S., Bhoyar P.K., Mundada A.S. Evaluation of in vitro antihelmintic activity of leaves of Butea monosperma. ijp [Internet]. 2022 Feb. 9 [cited 2024 Jun. 16];2(1):31-5. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/13

Issue

Section

Original Research Articles