Neuroprotective effect of Vinpocetine against 3- NP Induced reduction of body weight and oxidative stress in Rats

Authors

  • Meenakshi Ratra Department of Pharmacology, Sri Sai college of Pharmacy, Badhani, Pathankot-145001
  • PL Sharma Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
  • Rajesh Gupta Department of Pharmacology, Sri Sai college of Pharmacy, Badhani, Pathankot-145001

Keywords:

3- Nitropropionic acid, Vinpocetine, Huntington Disease

Abstract

Huntington’s disease is a progressive, degenerative disease characterized by abnormal body movements symptoms like chorea and a reduction of body weight. Recently, it has been reported that oxidative stress, which is one of the pathological hallmarks of various neurodegenerative disorders, also plays an important role in the pathogenesis of Huntington’s disease. 3- Nitropropionic acid, a neurotoxin treatment significantly reduction in body weight. Intraperitoneal administration of 3-nitropropionic acid (10 mg/kg for 14 days) caused significant loss of body weight and poor rentention of memory. Biochemical analysis revealed that 3-NP administration significantly increase in lipid peroxidation in the brains of rats. The present study demonstrated that inhibition of type 1 phosphodiesterase (PDE1) by vinpocetine (5, 10 & 20mg\kg) significantly reversed behavioral and biochemical dysfunction in 3-NP treated group. The result of the present study suggests facilitatory role of PDE1 enzyme in loss in body weight and oxidative stress following 3-NP injection.

References

. Vonsattel JP, DiFiglia M. Huntington

disease, J. Neuropathol Exp Neurol

;57:369-384.

. Martin JB. and Gusella JF. Huntington’s

disease: pathogenesis and management. N

Engl J. Med 1986; 315: 1267-1276.

. Cruz, V and Santamaria, A. Integrative

Hypothesis for Huntington’s disease: A

Brief Review of Experimental Evidence.

Physiol. Res 2007; 56: 513-526.

. La Fontaine MA, Geddes JW, Banks A

and Butterfield DA. Effect of exogenous

and endogenous antioxidants on 3-

nitropropionic acid – induced in vivo

oxidative stress and striatal lesions:

insights into Huntington’s disease. J

Neurochem 2000; 75: 1709- 1715.

. Kumar P, Padi SSV, Naidu PS and Kumar

A. Possible Neuroprotective of Curcumin

in Attenuating 3-Nitropropionic Acid –

Induced Neurotoxicity. Methods Find.

Exp. Clin. Pharmacol 2006; 17: 485- 92.

. KimYJ ,Yi ,Y Sapp, Wang Y, Cuiffo B,

Kegel, Qin ZH, Aronin, DiFiglia M.

Capase3- cleaved N- terminal fragments

of wild type and mutant huntingtin are

present in normal and Huntington’s

disease brains , associate with

membranes, undergo calpain – dependent

proteolysis. Proc. Natl. Acad Sci . U.S.A.

; 98: 12784- 12789.

. Vis JC, Van Huizen RT, Veerbeek MM,

de Waal RM, ten Donkelaar HJ and

Kremer B. Creatine protects against 3-

nitropropionic acid-induced cell death in

murine corticostriatal slice cultures. Brain

Res 2004; 1024: 16-24.

. Beal MF. Mitochondrial dysfunction in

neurodegenerative disease. Biochem

Biophy Acta 1998; 1366: 211-223.

. Nagakura M, Oosumi K, Hirano H,

Onishi Y. Pharmcogenomics and

therapeutics trategies for Dementia .

Science direct 2002; 34:357- 379.

. Puzzo D, Vitolo O , Trinchese F, Joel P,

Jacob AP, Arancio . Neurobiology of

Disease Amyloid β Peptide Inhibits

Activation of the Nitric

Oxide/cGMP/cAMP-Responsive

Element-Binding Protein Pathway during

Hippocampal Synaptic Plasticity. J

Neuroscience 2005; 25: 6887– 6897.

. Fujita SS, Zghb J, Hong . Species

differences in Brain phosphodiesterase

levels . J Neural Transm 2008; 41:185.

. Nibuya M , Nestler EJ, Duman RS.

Chronic antidepressant administration

increases the expression of cAMP

response element binding protein (CREB)

in rat hippocampus. J Neurosci 1996; 16:

–2372.

. Chun YJ, Kim MY, Guengerich FP.

Resveratrol is a selective human

cytochrome P450 1A1 inihibitor.

Biochem Biophys Rest Commun 1999;

:20-24.

. Song, Perides, Liu and YF .Expression of

full length polyglutamine expanded

Huntington distrupt growth factor

receptor signaling in rat. J Biolchem

; 277:6703-6707.

. Bishop VS, DM Farrell. The role of

cGMP and cAMP in active

thermoregulatory vasodilation. Neurobiol

Dis 1997; 272: R975- R981.

. O’Donnell JM and Zhang HT.

Antidepressant effects of inhibitors of

cAMP phosphodiesterase. Trends

Pharmacol. Sci 2004; 25: 158–163.

. K Tarnok, E Kiss, PGM Luiten, C

Nyakas, K Tihanyi, K Schlett ,and ULM

Eisel. Effects of Vinpocetine on

mitochondrial function and

neuroprotection in primary cortical

neurons. Curr Pharm Des 2008; 66: 63-

. Lugnier C: Cyclic nucleotide

phosphodiesterase superfamily.

Pharmacol Ther 2006; 109:366-398.

. Wills ED. Mechanism of lipid peroxide

formation in animal. Biochems J. 1966;

: 667-676.

. Kumar P, Padi SSV, Naidu PS and

Kumar A. Effect of resveratrol on 3-

nitropropionic acid- induced biochemical

and behavioural changes: possible

neuroprotective mechanisms. Behav.

Pharmacol, 2006 ; 17: 485- 492.

. Rose GM, Hopper A, De Vivo M and

Tehim A. Phosphodiesterase inhibitors

for cognitive enhancement. Curr Pharm

Des 2005; 11(26): 3329-3334.

. Vas A and Gulyas D. Eburnamine

derivatives and the brain. Med Res Ev

; 25: 737-57.

. Kaudac D and Mittlemon A , Serpico R,

Sinha AA, Natale C, Pani P, Simone S

and Farber E. Cell death: apoptosis versus

necrosis. Int J on col 2002; 21: 165- 70.

. Koutouzis TK , Borlongan, Scorcia and

Creese PR , Systemic 3-NP : long term

effects on locomotor behavior. Brain Res

; 646:242- 46.

. Tunez I, Montilla P, Munoz and Tariq

MC. Treatment with

dehydroepiandrosterone prevents

oxidative stress induced by 3-

nitropropionic acid in synaptosomes.

Pharmacology 2005; 74:113-118.

. Borlongan CV , Freeman TK, DW Cahill.

Behavioral pathology induced by repeated

injection of 3-NP mimic the symptoms of

HD . Brain Res 1995; 697: 254-257.

. Borlongan CV, Kanning K ,Freeman.

Free radical damage and oxidative stress

in Huntington’s disease. JFLA Med Assoc

; 83: 335-41.

. Haik KL, Haik, DA,Shear Sabel, Dunbar

GL, Quinolinic acid released from

polymeric brain implants causes

behavioral and neuroanatomical

alterations in a rodent model of HD. Exp

Neurol 2000; 163: 430- 439.

. Kodsi, Swerdlow. Mitochondrial 3-NP

produce abnormalities in rats that model

of HD. Depart Psych 1997; 231 : 103-07.

. Sun Y. Free radicals and antioxidant

enzymes. Free Radic Biol Med 1990; 8:

-99.

. Stolc S. Indole derivatives as

neuroprotectants .Life Sci 1950; 65:

-50.

. Santos MS, Durate AL, Oliveria.

Synaptosomal response to oxidative

stress: effects of Vinpocetine. Free Radic

Res 2000; 32: 57-66.

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Published

30-09-2011

How to Cite

1.
Meenakshi Ratra, PL Sharma, Rajesh Gupta. Neuroprotective effect of Vinpocetine against 3- NP Induced reduction of body weight and oxidative stress in Rats. ijp [Internet]. 2011 Sep. 30 [cited 2024 Nov. 13];3(3):362-9. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/116

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Original Research Articles