ound Healing Evaluation of Some Herbal Formulations Containing Curcuma Longa and Cynodon Dactylon Extract

Authors

  • Vinod M. Thakare TVES’s Hon’ble Loksevak Madhukarrao Chaudhari, College of Pharmacy, Faizpur , Tq: Yawal, Dist: Jalgaon. Pin:425503.
  • R. Y. Chaudhari TVES’s Hon’ble Loksevak Madhukarrao Chaudhari, College of Pharmacy, Faizpur , Tq: Yawal, Dist: Jalgaon. Pin:425503.
  • V.R. Patil TVES’s Hon’ble Loksevak Madhukarrao Chaudhari, College of Pharmacy, Faizpur , Tq: Yawal, Dist: Jalgaon. Pin:425503.

Keywords:

Curcuma longa, Cynodon dactylon, Dead space wound, Incision, Excision

Abstract

The wound healing effect of herbal cream formulated with Curcuma longa, and Cynodon dactylon embedded in different ointment bases (anionic, cationic and non-ionic) has been evaluated in vivo using the incision, excision and dead space tissue wound models, on Swiss wister rat. Curcuma longa, and Cynodon dactylon was extracted using Pet ether (60-800C ), chloroform, ethanol, methanol and water. The methanolic extract formulated as herbal preparations. The herbal preparations were used to treat wounds inflicted on experimental Swiss wister rat. The wound healing effects of the formulations were compared to that of a standard antibiotic. In all cases, there was a progressive decrease in wound area with time, indicating an efficacy of the formulations in healing the induced wounds. By the 16th day, the formulation containing 100 mg/g of Curcuma longa, and Cynodon dactylon in cationic base showed 100 % healing. The wound areas in the animals treated with the standard antibiotic, showed a 100% healing by the 17 th day, indicating that the plant extract, at that given concentration, had a better wound healing property.

References

. Taber, CW. Taber’s Cyclopedic Medical

Dictionary, 10th edition, F. A. Davies

Company, U. S. A. 1965.

. Thomas, J C.,Veterinary Pathology, 6th

edition, William’s and Wilkin, Maryland,

USA, 1997, pp. 150-156.

. Karl M., Lacrix J.V, Preston H.H. Canine

surgery, 4th edition, American Veterinary

Publications, California., 1995, pp 42-45.

. Ahmed, S., Reza, M.S., Haider, S.S.,

Jabbar, A., Antimicrobial activity of

Cynodon dactylon. Fitoterapia., 1994,65,

–464.

. Balachandran P., Govindarajan R.,

Ayurvedic drug discovery, Expert

Opinion Drug Dis., 2007, 2 (12),1631-

. Jarald, E.E., Joshi S.B., Jain D.C.,

Antidiabetic activity of aqueous

extract and non polysaccharide

fraction of Cynodon dactylon Pers.

Ind J Exp Bio., 2008,46: 660-667.

. Santhi R., Kalaiselvi K., Annapoorani S.,

Antioxidant efficacy of Cynodon dactylon

leaf protein against ELA implanted swiss

albino mice, J Pharm Res 2010, 3(2),228-

. Saradha Devi1 K. M, Annapoorani1 S.

Ashokkumar K., Hepatic antioxidative

potential of ethyl acetate fractionof

Cynodon dactylon in Balb/c mice, J Med

Plants Res., 2011,5(6), pp. 992-996.

. Govindarajan, R., Vijayakumar,M.,

Pushpangadan, P., Antioxidant approach

to disease management and the role of

‘Rasayana’ herbs of Ayurveda. J

Ethnopharmacol., 2005,99, 165–178.

. Auddy, B., Ferreira, M., Blasina, F.,

Lafon, L., Arredondo, F., Dajas, F.,

Tripathi, P.C., Seal, T., Mukherjee, B.,

Screening of antioxidant activity of 3

Indian medicinal plants, traditionally used

for the management of neurogenerative

diseases. J Ethnopharmacol., 2003,84,

–138.

. Surh Y.J, Anti-tumor promoting potential

of selected spice ingredients with antioxidative and anti-inflammatory

activities-a short review. Food and

Chemical Toxicology., 2002, 40, 1091-

. Iyengar M.A., Pattabhi M., Rao R., Antimicrobial activity of the essential oils of

Curcuma longa leaves. Ind Drugs., 1995,

(6),249-250.

. Chandic R,. Dash S.K,. Mishra R.K,,Anti

E. coli activity of Turmeric essential oil.

Ind Drugs., 2001, 38 (3): 106-111.

. Artizzu, N., Bonsignore, L., Cottiglia, F.,

Loy, G., Studies on the diuretic and

antimicrobial activity of Cynodon

dactylon essential oil. Fitoterapia

.,1996.67, 174–176.

. Raveendra Pai M., Acharya L.D., Udupa

N., Evaluation of antiplaque activity of

Curcuma longa leaf extract gel a 6-week

clinical study. J Ethanopharmacol., 2004,

,99-103.

. Subramanian, S., Nagarajan, S., Wound

healing activity of Pongamia pinnata and

Cynodon dactylon. Fitoterapia., 1988,59,

–44.

. Thakare V.M,. Chaudhari R.Y, Patil

V.R., Promotion of cutaneous wound

healing by herbal formulation containing

Azadirachta indica and Cynodon dactalon

extract in wistar rats, Int J Pharm Res

Dev., 2011,3(4), 80 – 86.

. Thaker A.M, Anjaria J.V., Anti-microbial

and infected wound healing response of

some traditional drugs. Ind. J. Pharm.,

, 18:171-174.

. Morton J.J.P., Malone M.H., Evaluation

of vulnerary activity by an open wound

procedure in rats. Arch.Int.

Pharmacodyn., 1972, 196,117-126.

. Ehrlich P.H., Thomas K. H,. Effects of

Cortisone and vitamin A on wound

healing, Annal of Surg.,1968,168,3,324-

. Lee, K.H., Krei, C.H, Studies on the

mechanism of action of salicylate

retardation of wound healing by aspirin, J

Pharm. Sci., 1968, 57, 1042-1043.

. Woessner J. F, Jr., Determination of

hydroxyproline in tissues and protein

samples containing small proportion of

this amino .,Arch Biochem Biophy.

,93, 440-447.

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Published

30-09-2011

How to Cite

1.
Vinod M. Thakare, R. Y. Chaudhari, V.R. Patil. ound Healing Evaluation of Some Herbal Formulations Containing Curcuma Longa and Cynodon Dactylon Extract. ijp [Internet]. 2011 Sep. 30 [cited 2024 Nov. 13];3(3):325-32. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/111

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Original Research Articles